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PPM1D Polyclonal Antibody

CAT: 0866-RD252172A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD252172A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Description
This is a PPM1D Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
EC 3.1.3.16, p53 induced protein phosphatase 1, p53-induced protein phosphatase 1, PP2C delta, PP2C-delta, PP2CD, Ppm1d, PPM1D, Protein phosphatase 1D, protein phosphatase 1D magnesium-dependent delta isoform , Protein phosphatase 2C delta isoform, Protein phosphata
Swiss Prot
O15297
Accession Number
BC033893
Reactivity
Human, Mouse
Immunogen
Fusion protein of human PPM1D
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.5 mg/mL
Dilution
IHC 1:50-1:300, ELISA 1:2000-1:5000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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