PPM1D Polyclonal Antibody

• Background:

  The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

• Description:

  This is a PPM1D Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  EC 3.1.3.16, p53 induced protein phosphatase 1, p53-induced protein phosphatase 1, PP2C delta, PP2C-delta, PP2CD, Ppm1d, PPM1D, Protein phosphatase 1D, protein phosphatase 1D magnesium-dependent delta isoform , Protein phosphatase 2C delta isoform, Protein phosphata

• Swiss Prot:

  O15297

• Accession Number:

  BC033893

• Reactivity:

  Human, Mouse

• Immunogen:

  Fusion protein of human PPM1D

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC, ELISA

• Purification Method:

  Antigen affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.5 mg/mL

• Dilution:

  IHC 1:50-1:300, ELISA 1:2000-1:5000

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG