Anti-Human CD45 PTPRC Monoclonal Antibody iFluor488 Conjugated, Flow Validated

• Description:

  Boster Bio Anti-Human CD45 PTPRC Monoclonal Antibody iFluor488 Conjugated, Flow Validated (Catalog# FC00555-iFluor488) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

• Synonyms:

  Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

• Gene Name:

  PTPRC

• UniProt:

  P08575

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human T lymphocytes

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: F10-89-4

• Conjugation:

  IFluor488

• Applications:

  Flow Cytometry

• Field of Research:

  Adapters, Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Transmembrane, Tyrosine Phosphatases

• Purification:

  Affinity column chromatography

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Dilution:

  User needs to optimize the dilution ratio for this antibody.

• Form:

  Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

• Function:

  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) . .

• Molecular Weight:

  147254 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 2-8°C. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG2a, k

• Other Gene Names:

  Receptor-type tyrosine-protein phosphatase C

• Subcellular Location:

  Membrane; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts.