Anti-CD45 PTPRC Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-CD45 PTPRC Rabbit Monoclonal Antibody catalog # M00555-1. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

• Synonyms:

  Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

• Gene Name:

  Receptor-type tyrosine-protein phosphatase C

• UniProt:

  P08575

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human CD45

• Clonality:

  Monoclonal

• Clone:

  Clone: CBI-16

• Tissue Specificity:

  Ubiquitous.

• Applications:

  WB, IHC, ICC, IF, Flow Cytometry

• Field of Research:

  Adapters, Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Transmembrane, Tyrosine Phosphatases

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) . .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:100
  FC 1:20

• Other Gene Names:

  PTPRC

• Subcellular Location:

  Membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.

• Protein Name:

  T-cell surface glycoprotein CD4