Anti-CD45 PTPRC Antibody

• Description:

  Boster Bio Anti-CD45 PTPRC Antibody catalog # A00555. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

• Gene Name:

  PTPRC

• UniProt:

  P08575

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human CD45. AA range:981-1030

• Applications:

  WB

• Purification:

  Immunogen affinity purified

• Dilution:

  User needs to optimize the dilution ratio for this antibody.

• Form:

  Liquid

• Function:

  Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) . .

• Molecular Weight:

  147254 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Receptor-type tyrosine-protein phosphatase C

• Subcellular Location:

  Membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.