APOA1 Apolipoprotein A-I Human

• Description:

  APOA1 Human isolated from Human HDL is a single, glycosylated, polypeptide chain having a molecular mass of 28.3kDa. APOA1 is purified using delipidation and gel permeation chromatographic technique.

• Synonyms:

  Apolipoprotein A-I; Apo-AI; ApoA-I; APOA1; MGC117399

• Gene Name:

  APOA1

• UniProt:

  P02647

• Reactivity:

  Human

• Tissue Specificity:

  Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

• Source:

  Human HDL

• Purification:

  Greater than 95.0% as determined by SDS-PAGE.

• Form:

  Sterile filtered colorless solution.

• Function:

  Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT) . As part of the SPAP complex, activates spermatozoa motility.

• Shipping Conditions:

  Available

• Storage Conditions:

  APOA1 although stable at 4°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze thaw cycles.

• Other Gene Names:

  Apolipoprotein A-I

• Subcellular Location:

  Secreted.