EXOSC9 Exosome Component 9 Human Recombinant Protein

• Description:

  EXOSC9 is a Full-length cDNA coding for the human PM/Scl 75c-beta isoform having a molecular mass of 64 KDa. EXOSC9 protein is fused to a hexa-histidine purification tag. Applications: Western blot with polymyositis patient sera and monoclonal anti-hexa-His-tag antibody.

• Synonyms:

  Exosome component 9; PM/Scl-75; PMSCL1; RRP45; Rrp45p; p5; p6; Polymyositis/scleroderma autoantigen 1-75kDa; Autoantigen PM/Scl 1; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; EC 3.1.13

• Gene Name:

  EXOSC9

• UniProt:

  Q06265

• Reactivity:

  Human

• Source:

  Sf9 insect cells

• Applications:

  WB

• Purification:

  Greater than 95% as determined by SDS-PAGE.

• Function:

  Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

• Other Gene Names:

  Exosome complex component RRP45

• Subcellular Location:

  Cytoplasm. Nucleus