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9-Hydroxyellipticin

CAT: 0804-HY-101775Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101775Size:1 Each
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Description
9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice[1].
CAS Number
51131-85-2
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/9-hydroxyellipticin.html
Smiles
OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1
Molecular Formula
C17H14N2O
Molecular Weight
262.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89 (2) :281-6.|[2]Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89 (1) :21-8.|[3]G Renault, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89 (2) :281-6.|[4]Le Pecq JB, et al. A new antitumoral agent: 9-hydroxyellipticine. Possibility of a rational design of anticancerous drugs in the series of DNA intercalating drugs. Proc Natl Acad Sci U S A. 1974 Dec;71 (12) :5078-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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