Human CTGF / CCN2 Protein, Tag Free

• Background:

  Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.

• Description:

  Human CTGF Protein, Tag Free (CTF-H5113) is expressed from E. coli cells. It contains AA Gly 253 - Ala 349 (Accession # Q5M8T4-1 ).

• Specifications:

  This protein carries no "tag". The protein has a calculated MW of 11.2 kDa. The protein migrates as 10-11 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

• Expression Region:

  Gly 253 - Ala 349

• Host:

  E. coli

• Target:

  CTGF

• Conjugation:

  Unconjugated

• Tag:

  Native

• Source:

  Human

• Stability:

  The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

• Endotoxin:

  0.1 EU per μg

• Purity:

  95%

• Format:

  Liquid

• Buffer:

  PBS, pH7.4

• Additives:

  Glycerol

• Molecular Weight:

  11.2 kDa

• Shipping Conditions:

  Dry ice

• Storage Conditions:

  -70°C