Rhesus macaque CTGF / CCN2 Protein, His Tag

Rhesus macaque CTGF / CCN2 Protein, His Tag

• Background: Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
• Description: Rhesus macaque CTGF, His Tag (GTF-R52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ala 349 (Accession # H9FQD5-1).
• Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.3 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Gln 27 - Ala 349
• Host: HEK 293
• Target: CTGF
• Conjugation: Unconjugated
• Tag: C-10×His
• Source: Rhesus macaque
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 90%
• Bioactivity: Immobilized Rhesus macaque CTGF, His Tag (Cat. No. GTF-R52H4) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CTGF Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).
• Format: Powder
• Buffer: 5 mM HAC, 100 mM NaCl, pH5.5
• Additives: Sucrose
• Molecular Weight: 37.3 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C