Human CTGF / CCN2 Protein, Tag Free

Human CTGF / CCN2 Protein, Tag Free

• Background: Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
• Description: Human CTGF Protein, Tag Free (CTF-H5113) is expressed from E. coli cells. It contains AA Gly 253 - Ala 349 (Accession # Q5M8T4-1 ).
• Specifications: This protein carries no "tag". The protein has a calculated MW of 11.2 kDa. The protein migrates as 10-11 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
• Expression Region: Gly 253 - Ala 349
• Host: E. coli
• Target: CTGF
• Conjugation: Unconjugated
• Tag: Native
• Source: Human
• Stability: The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
• Endotoxin: 0.1 EU per μg
• Purity: 95%
• Format: Liquid
• Buffer: PBS, pH7.4
• Additives: Glycerol
• Molecular Weight: 11.2 kDa
• Shipping Conditions: Dry ice
• Storage Conditions: -70°C