Dynasore

Dynasore

• CAS Number: 304448-55-3
• UNSPSC Description: Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM. Dynasore blocks cell migration.
• Target Antigen: Autophagy; Dynamin; HSV; Virus Protease
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy;Cytoskeleton
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/Dynasore.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(C1=C(O)C=C2C=CC=CC2=C1)N/N=C/C3=CC=C(O)C(O)=C3
• Molecular Weight: 322.31
• References & Citations: [1]Macia E, et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun;10(6):839-50.|[2]Mues MB, et al. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul;89(13):6673-84.|[3]Gao D, et al. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One. 2013 Apr 15;8(4):e60967.|[4]Li G, et al. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2016 Nov 7.|[5]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25(1):24-38.AAPS PharmSciTech. 2023 Feb 15;24(2):69.|Adv Funct Mater. 2023 Jan 15.|Adv Funct Mater. 2024 May 1.|Adv Healthc Mater. 2024 Jul 16:e2401460.|Adv Mater. 2022 Jul 28;e2204287.|Adv Sci (Weinh). 2022 Dec 11;e2204871.|Anal Chem. 2020 Jan 21;92(2):2103-2111.|Antioxidants (Basel). 2022, 11(12), 2307.|Arab J Chem. 2020, 13 (1): 2558-2567.|Biol Res. 2023 Mar 11;56(1):10.|Biomaterials. 2022 May;284:121529.|Cancer Immunol Res. 2022 May 17;canimm.0652.2021.|Cell Commun Signal. 2020 Nov 4;18(1):176.|Cell Death Differ. 2024 Aug 8.|Cell Rep. 2022 Jun 14;39(11):110943.|Comput Struct Biotec. 2021;19:1933-1943.|Drug Deliv. 2018 Nov;25(1):1066-1079. |EBioMedicine. 2022 Jul 28;82:104181.|Elife. 2022 Jun 28;11:e78044.|Environ Sci Technol. 2023 May 30.|Eur J Cell Biol. 2019 Jan;98(1):36-50.|Eur J Pharmacol. 2021 May 25;174203.|FEBS J. 2024 Sep 15.|Food Chem. 2024 Sep 8;463(Pt 1):141196.|Front Cell Dev Biol. 2021 Jul 7;9:687322.|Int J Biol Macromol. 2022 Jun 16;S0141-8130(22)01308-3.|Int J Biol Sci. 2024 Sep 3;20(12):4713-4730.|Int J Pharm. 2024 Apr 25:655:124072.|J Am Chem Soc. 2018 Dec 12;140(49):17234-17240.|J Extracell Vesicles. 2021 Jul;10(9):e12117.|J Hazard Mater. 2021 Sep 5;417:126092.|J Virol. 2021 Sep 29;JVI0134521.|Mov Disord. 2023 Oct 5.|Nano Lett. 2019 Nov 13;19(11):8010-8020. |Nat Commun. 2021 Jun 9;12(1):3481.|Nat Nanotechnol. 2020 Dec;15(12):1043-1052.|Neurotox Res. 2019 Jul;36(1):108-116.|Oncogene. 2018 Jan 4;37(1):116-127. |PLoS Pathog. 2021 Jul 21;17(7):e1009752.|Redox Biol. 2022 Apr;50:102257.|Research Square Preprint. 2021 Aug.|Research Square Preprint. 2023 Apr 19.|Research Square Preprint. 2023 Aug 7.|Research Square Print. 2022 May.|Sci Bull. 2020 Jul.|Sci China Life Sci. 2021 May 27;1-21.|Sci Rep. 2023 May 25;13(1):8479.|Signal Transduct Target Ther. 2024 Sep 26;9(1):254.|Small Methods. 2020 Dec 18.|SSRN. 14 Feb 2022.|SSRN. 2023 Sep 15.|Toxins. 2023 Feb 6;15(2):132.|Virology. 2024 Dec.|Virus Res. 2020 Jan 15;276:197806.|J Autoimmun. 2023 Mar 8;136:103012.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported