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CD73 Inhibitor Screening Kit

CAT: 0716-EP-166-96testsSize: 96 TestsDry Ice: NoHazardous: No
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CAT#:0716-EP-166-96testsSize:96 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.
Description
CD73 Inhibitor Screening Kit is expressed from Human -.
Reactivity
Human
Target
CD73
Applications
This kit is developed for screening inhibitors of CD73.
Stability
Unopened kit should be stored at 2°C-8°C upon receiving. Find the expiration date on the outside packaging and do not use reagents past their expiration date. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
Format
Solid
Shipping Conditions
Blue ice
Storage Conditions
2-8°C
Package Size
96tests*1
Species
Human

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