Anti-Importin subunit alpha-1 KPNA2 Antibody

Anti-Importin subunit alpha-1 KPNA2 Antibody

• Background: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind "cargo" and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.
• Description: Boster Bio Anti-Importin subunit alpha-1 KPNA2 Antibody (Catalog # A01776). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
• Synonyms: QIP2, RCH1, IPOA1, SRP1alpha, SRP1, Importin subunit alpha-1, Karyopherin subunit alpha-2
• CAS Number: 9007-83-4
• Gene Name: KPNA2
• UniProt: P52292
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: KPNA2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA2. The immunogen is located within amino acids 40 - 90 of KPNA2.
• Clonality: Polyclonal
• Applications: ELISA, WB, IHC-P, IF
• Purification: KPNA2 Antibody is affinity chromatography purified via peptide column.
• Concentration: 1 mg/mL
• Form: Liquid
• Molecular Weight: 57862 MW
• Components: KPNA2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Storage Conditions: KPNA2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Fragment: IgG