Anti-Importin subunit alpha-7 KPNA6 Antibody

• Description:

  Boster Bio Anti-Importin subunit alpha-7 KPNA6 Antibody catalog # A07295-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Importin subunit alpha-7; Karyopherin subunit alpha-6; KPNA6; IPOA7;

• Gene Name:

  KPNA6

• UniProt:

  O60684

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Tissue Specificity:

  Widely expressed.

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

• Molecular Weight:

  60030 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Importin subunit alpha-7

• Protein Name:

  Importin subunit alpha-7