Anti-APC5 ANAPC5 Antibody

• Background:

  Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC5 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC5, it is thought that APC5 associates with other APC/C components APC1, APC4, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.

• Description:

  Boster Bio Anti-APC5 ANAPC5 Antibody (Catalog # A08280-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  APC5, APC5, Anaphase-promoting complex subunit 5, Cyclosome subunit 5

• Gene Name:

  ANAPC5

• UniProt:

  Q9UJX4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  APC5 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC5. The immunogen is located within amino acids 480 - 530 of APC5.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  APC5 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

• Molecular Weight:

  85077 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  APC5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Anaphase promoting complex subunit 5

• Prediction Reactivity:

  Chicken

• Protein Name:

  Anaphase promoting complex subunit 5