Anti-Aipl1 Antibody

• Background:

  Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.

• Description:

  Boster Bio Anti-Aipl1 Antibody (Catalog # A05356-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  LCA4, AIPL2, Aryl-hydrocarbon-interacting protein-like 1

• Gene Name:

  AIPL1

• UniProt:

  Q9NZN9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Aipl1 antibody was raised against a 18 amino acid synthetic peptide near the center of the human Aipl1. The immunogen is located within amino acids 140 - 190 of Aipl1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Homeostasis

• Purification:

  Aipl1 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  May be important in protein trafficking and/or protein folding and stabilization.

• Molecular Weight:

  43903 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Aipl1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Aryl hydrocarbon receptor interacting protein-like 1

• Subcellular Location:

  Cytoplasm

• Prediction Reactivity:

  Bovine

• Protein Name:

  Aryl hydrocarbon receptor interacting protein-like 1