Anti-CPSF6 Antibody

• Description:

  Boster Bio Anti-CPSF6 Antibody catalog # A04551. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Cleavage and polyadenylation specificity factor subunit 6 ; Cleavage and polyadenylation specificity factor 68 kDa subunit; CPSF 68 kDa subunit; Cleavage factor Im complex 68 kDa subunit

• Gene Name:

  CPSF6

• UniProt:

  Q16630

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human CPSF6 (Q16630) .

• Clonality:

  Polyclonal

• Applications:

  WB, IHC, ICC, IF, IP

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085) . CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600) . Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085) . The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'- UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085) . CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486) . Plays a role in mRNA export (PubMed:19864460) .

• Molecular Weight:

  59210 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Cleavage and polyadenylation specificity factor subunit 6

• Subcellular Location:

  Nucleus

• Protein Name:

  Cleavage and polyadenylation specificity factor subunit 6