ATG7-IN-3

• UNSPSC Description:

  ATG7-IN-3 (compound 18) is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4[1].

• Target Antigen:

  Atg7; Atg8/LC3; Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/atg7-in-3.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CSC1=NN([C@]2([H])O[C@@H]([C@H](C2)O)COS(N)(=O)=O)C3=NC=NC(N)=C31

• Molecular Weight:

  376.41

• References & Citations:

  [1]Huang SC, et al. Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115681.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2226229-76-9