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K41498

CAT: 0013-GTR19029220Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19029220Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This potent small molecule is a highly selective CRF2 receptor antagonist, with Ki values of 0.66 nM and 0.62 nM for human CRF2α and CRF2β, respectively, and >600-fold selectivity over CRF1. It effectively inhibits sauvagine-stimulated cAMP accumulation in vitro and blocks urocortin-induced hypotension in rat models in vivo, making it a valuable tool for studying cardiovascular and stress-related disorders.
Field of Research
Pharmacology & Drug Discovery
Molecular Weight
3632.26
Storage Conditions
-20°C
Notes
For research use only.

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