Recombinant Cynomolgus FGL1 (C-Avi-6His) Biotinylated

• Background:

  Fibrinogen-like protein 1 (FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3.

• Abbreviation:

  FGL1

• Synonyms:

  FGL1; Fibrinogen-like protein 1; HFREP-1; HP-041; Hepassocin; LFIRE-1

• UniProt:

  A0A2K5X990

• Accession Number:

  A0A2K5X990

• Expression System:

  HEK293 Cells

• Conjugation:

  Biotinylated

• Tag:

  C-Avi-His

• Sequence:

  Leu23-Ile312

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  34.8 kDa

• Observed Molecular Weight:

  36 kDa

• Formulation:

  Supplied as a 0.2 µm filtered solution of 20mM Tris-HCl, 300mM NaCl, 10% Glycerol, 2mM EDTA, pH 8.0.

• Species:

  Cynomolgus macaques