Recombinant Human FGL1 (C-Fc)

• Background:

  Fibrinogen-like protein 1 (FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .

• Abbreviation:

  FGL1

• Synonyms:

  FGL1; Fibrinogen-like protein 1; HFREP-1; HP-041; Hepassocin; LFIRE-1

• UniProt:

  Q08830

• Accession Number:

  Q08830

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Leu23-Ile312

• Field of Research:

  Cardiovascular

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  60.9 kDa

• Observed Molecular Weight:

  55 - 65 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, 5% Trehalose, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.

• Species:

  Human