Recombinant Mouse TGFβ1/TGFB1 Protein

Recombinant Mouse TGFβ1/TGFB1 Protein

• Background: Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
• Abbreviation: TGFβ1;TGFB1
• Synonyms: CED, CEDLAP, DPD1, TGF-b1, TGF-beta 1 protein, TGF-beta-1, TGFB, TGFB1, TGFbeta, latency-associated peptide, transforming growth factor beta-1
• CAS Number: 9000-83-3
• UniProt: P04202
• Accession Number: P04202
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: None
• Sequence: Ala279-Ser390
• Applications: Cell culture
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 5-25 pg/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 13 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.