Recombinant Mouse Interleukin-22/IL-22 Protein

Recombinant Mouse Interleukin-22/IL-22 Protein

• Background: Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.
• Abbreviation: Interleukin-22;IL-22
• Synonyms: Interleukin, Cytokine Zcyto, IL-D, TIFIL, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, IL-22a, IL-D110, IL-TIF, Interleukin-22a, TIFa, TIFIL-23, UNQ3099/PRO10096, zcyto18, Interleukin-22, T-cell-derived-inducible, factor(IL-TIF), Interleukin-22a(IL-22a), IL-TIF alpha, IL-10-related, IL-22, Il22a, Iltif, Iltifa, Il22, TIFa
• CAS Number: 9000-83-3
• UniProt: Q9JJY9
• Accession Number: Q9JJY9
• Host: E. coli
• Origin Species: Mouse
• Tag: C-His
• Sequence: Leu34-Val179
• Applications: Cell culture
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to induce IL-10 secretion in COLO205 cells. The ED₅₀ for this effect is <0.3 ng/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 17 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.