Recombinant Human Interleukin-22/IL-22 Protein

Recombinant Human Interleukin-22/IL-22 Protein

• Background: Interleukin-22(IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
• Abbreviation: IL-22
• Synonyms: UNQ, IL-D, Interleukin, Cytokine Zcyto, TIFIL, zcyto, IL22, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, UNQ3099/PRO10096, UNQ3099, Interleukin-22, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, PRO10096, IL-D110, ILTIF, IL-TIF, TIFa, TIFIL-23, zcyto18
• CAS Number: 9000-83-3
• UniProt: Q9GZX6
• Accession Number: Q9GZX6
• Host: HEK293 Cells
• Origin Species: Human
• Tag: None
• Sequence: Ala34-Ile179
• Field of Research: immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 25-35 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.