Recombinant Mouse IL-1A/IL-1α Protein

Recombinant Mouse IL-1A/IL-1α Protein

• Background: Mouse Interleukin-1 (IL-1) designates two proteins, IL-1α and IL-1β, which are the products of distinct genes, but recognize the same cell surface receptors. IL-1α and IL-1β are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa.
• Abbreviation: IL-1A;IL-1α
• Synonyms: Hematopoietin, IL1F, Hematopoietin-1, IL1, IL1-A, IL1F1, IL-1α, Preinterleukin 1 Alpha, Pro-Interleukin-1-Alpha, Il-1a, Interleukin-1 alpha, IL-1 alpha, Il1a
• CAS Number: 9000-83-3
• UniProt: P01582
• Accession Number: P01582
• Host: E. coli
• Origin Species: Mouse
• Tag: C-His
• Sequence: Ser115-Ser270
• Applications: Cell culture
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to induce D10.G4.1 cells proliferation.The ED₅₀ for this effect is <5 pg/mL.The specific activity of recombinant mouse IL-1 alpha is > 2 x 10⁸ IU/mg.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 20 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.