Recombinant Mouse EphB4/HTK Protein (Fc Tag)

Recombinant Mouse EphB4/HTK Protein (Fc Tag)

• Background: Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.
• Synonyms: AI042935, Htk, MDK2, Myk1, Tyro11
• CAS Number: 9000-83-3
• UniProt: P54761
• Accession Number: P54761-1
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-hFc
• Sequence: Met 1-Ala 539
• Applications: ELISA
• Purity: > 97 % as determined by reducing SDS-PAGE.
• Bioactivity: Immobilized mouse EPHB2-His at 10 μg/mL (100 μl/well) can bind mouse EPHB4-Fc, The EC50 of mouse EPHB4-Fc is 15 ng/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 110 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.