Recombinant Human EphB4/HTK Protein

Recombinant Human EphB4/HTK Protein

• Background: Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore; EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation; extracellular matrix remodeling; and invasive potential are important mechanisms of tumor suppression. Therefore; Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.
• Synonyms: HTK, MYK1, TYRO11
• CAS Number: 9000-83-3
• UniProt: P54760
• Accession Number: NP_004435.3
• Host: HEK293 Cells
• Origin Species: Human
• Tag: None
• Sequence: Met 1-Ala 539
• Applications: ELISA
• Field of Research: Signal Transduction;Cardiovascular;Neuroscience;Cancer;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Immobilized human EphB4 at 2 μg/ml (100 μl/well) can bind human EphrinB2 with a linear range of 1-125 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 65-70 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.