Recombinant Human CD68/SR-D1 (C-Fc)

• Background:

  CD68, also called Scavenger Receptor D1 (SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoprotein that belongs to the LAMP family. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. CD68 is also a biomarker of rheumatoid arthritis and Hodgkin's lymphoma. CD68 influences the functions of cells through NF-kB/focal adhesion kinase pathway (7) . In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 to enhance the cell immunity.

• Abbreviation:

  CD68; SR-D1

• Synonyms:

  CD68; CD68 antigenmacrophage antigen CD68; CD68 molecule; Macrosialin; SCARD1; SR-D1; SRD1; gp110

• UniProt:

  P34810

• Accession Number:

  P34810

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Asn22-Ile320

• Field of Research:

  Immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  58.5 kDa

• Observed Molecular Weight:

  70-100 kDa

• Species:

  Human