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Recombinant CD68 Monoclonal Antibody

CAT: 0763-AN300590PSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0763-AN300590PSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Abbreviation
CD68
UniProt
Q4FZY1
Host
Rabbit
Reactivity
Rat
Immunogen
Recombinant Rat CD68 Protein
Clonality
Monoclonal
Clone
12B4
Conjugation
Unconjugated
Applications
IHC-P
Purification
Protein A
Concentration
1 mg/mL
Dilution
IHC-P 1:1000-1:4000
Buffer
0.2 μm filtered solution in PBS
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Isotype
IgG

UniProtKB · Q4FZY1

Macrosialin

Q4FZY1_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
Q4FZY1
Review status
UniProtKB unreviewed (TrEMBL)
Gene
Cd68
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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