Recombinant Human NPRC/NPR3 (C-Fc)

• Background:

  Atrial Natriuretic Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic peptide receptors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Osteocrin was found to be a specific ligand to NPR3. NPR3 is necessary for Osteocrin to regulate femoral, tibial, and metatarsal bone elongation.

• Abbreviation:

  NPRC, NPR3

• Synonyms:

  ANP-C; ANPR-C; ANPRC; C5orf23; NPR-C; NPR3; NPRC

• UniProt:

  P17342

• Accession Number:

  P17342

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Thr24-Glu481

• Field of Research:

  Signal Transduction; Cardiovascular;

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  77.5 kDa

• Observed Molecular Weight:

  90 - 100 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.

• Species:

  Human