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Recombinant Human CD99/MIC2 (C-6His)

CAT: 0763-PKSH033876-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH033876-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD99 is a type I transmembrane glycoprotein and the founding member of the CD99 family of molecules. The extracellular domain of CD99 contains no identifiable motifs, its cytoplasmic region, although short, does have signal transduction capability. Cells known to express CD99 include fibroblasts, neutrophils, T cells, double positive thymocytes, CD34+ stem cells, monocytes and endothelial cells. Two types of CD99 isoforms have been classified. Native human CD99 is referred to as the long, or type I isoform. The best studied type II isoform shows an Asp-Gly substitution for the C terminal 27 amino acids. The type I and II isoforms have distinctive signal transduction pathways (FAKsrc for type I PI3K plus srcERK1/2 for type II), and mediate clearly different biological outcomes. Homophilic interaction between CD99 on the neutrophil and CD99 on the endothelial cell regulates the transendothelial migration of neutrophils during inflammation. Human CD99 has 48% aa sequence identity to mouse CD99.
Abbreviation
CD99; MIC2
Synonyms
12E7; CD99; CD99 Antigen; E2 Antigen; MIC2; MIC2X; MIC2Y; Protein MIC2; T-Cell Surface Glycoprotein E2
UniProt
P14209
Accession Number
P14209
Expression System
HEK293 Cells
Tag
C-His
Sequence
Asp23-Asp122
Field of Research
Signal Transduction; Cancer; immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
11.1 kDa
Observed Molecular Weight
18 kDa
Species
Human

UniProtKB · P14209

CD99 antigen

CD99_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14209
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD99
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A6NIW1, O00518, Q6ICV7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

PTM

GlycoproteinPhosphoprotein

Cellular component

Membrane

Domain

SignalTransmembraneTransmembrane helix

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