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Recombinant Human Notch2 (C-6His)

CAT: 0763-PKSH034023-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH034023-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Human Notch-2 ECD (aa 26-530) shows 93%, 93%, 96% and 96% aa identity with the corresponding regions of mouse, rat, canine, and bovine Notch-2, respectively. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.
Abbreviation
Notch2
Synonyms
AGS2; HJCYS; Notch homolog 2; Notch-2; Notch2; hN2
UniProt
Q04721
Accession Number
Q04721
Expression System
HEK293 Cells
Tag
C-His
Sequence
Leu26-Gln530
Field of Research
Neuroscience; epigenetics and nuclear signal; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
54.9 kDa
Observed Molecular Weight
60-70 kDa
Species
Human

UniProtKB · Q04721

Neurogenic locus notch homolog protein 2

NOTC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04721
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NOTCH2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Notch 2, hN2
EC number
—
Processing
Precursor
Secondary accessions
Q5T3X7, Q99734, Q9H240
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinReceptor

Domain

ANK repeatEGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Cell membraneCytoplasmMembraneNucleus

Biological process

DifferentiationNotch signaling pathwayTranscriptionTranscription regulation

Disease

Disease variantOsteoporosis

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

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