Recombinant Human Siglec-7/CD328 (C-6His)

Recombinant Human Siglec-7/CD328 (C-6His)

• Background: Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains. Eleven human Siglecs have been cloned and characterized. Human Siglec-7 encodes a 467 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. Siglec-7 exists as a monomer on the cell surface and is expressed on natural killer cells, CD8+ T cells and monocytes. It binds equally well to both alpha 2,3- and alpha 2,6-linked sialic acid. The gene encoding Siglec-7 was mapped to chromosome 19q13.3.
• Abbreviation: Siglec-7;CD328
• Synonyms: CDw329, Protein FOAP-9, SIGLEC9, Sialic acid-binding Ig-like lectin 9, Siglec-9
• CAS Number: 9000-83-3
• UniProt: Q9Y286
• Accession Number: Q9Y286
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Gln19-Leu353
• Field of Research: Cardiovascular;Neuroscience;immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 50-70 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.