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Recombinant Human Siglec-8 (C-mFc)

CAT:
763-PKSH033960-02
Size:
10 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Recombinant Human Siglec-8 (C-mFc) - image 1
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Recombinant Human Siglec-8 (C-mFc)

  • Background: Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 115 aa cytoplasmic domain with two tyrosine based signaling motifs. Alternative splicing generates additional isoforms that either lack most of the second Ig-like domain or have a substituted cytoplasmic domain without the signaling motifs. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation. It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
  • Abbreviation: Siglec-8
  • Synonyms: CD329 antigen, CDw329, SAF-2, SAF2, SAF2SAF-2, Siglec-8, Siglec8
  • CAS Number: 9000-83-3
  • UniProt: Q9NYZ4
  • Accession Number: Q9NYZ4
  • Host: HEK293 Cells
  • Origin Species: Human
  • Tag: C-mFc
  • Sequence: Met17-Ala363
  • Field of Research: Signal Transduction;immunology;
  • Purity: > 95 % as determined by reducing SDS-PAGE.
  • Bioactivity: Not validated for activity
  • Reconstitution: Please refer to the printed manual for detailed information.
  • Molecular Weight: 80-100 kDa
  • Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
  • Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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