Recombinant Human SIRP gamma/CD172g Protein (Fc Tag)

• Background:

  Signal-Regulatory Protein Gamma (SIRPG) is a member of the signal-regulatory protein (SIRP) family and also belongs to the immunoglobulin superfamily. SIRPG is detected in the liver, and at very low levels in the brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRPG is an immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG as receptor-type transmembrane glycoproteins is involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

• Abbreviation:

  SIRP gamma; CD172g

• Synonyms:

  CD172 Antigen-Like Family Member B; CD172g; SIRP-Beta-2; SIRP-Gamma; SIRP-b2; SIRPB2; SIRPG; Signal-Fegulatory Protein Beta-2; Signal-Regulatory Protein Gamma

• UniProt:

  Q9P1W8

• Accession Number:

  Q9P1W8

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Glu29-Pro360

• Field of Research:

  Immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 90 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  63.9 kDa

• Observed Molecular Weight:

  80 kDa

• Species:

  Human