Recombinant Human STAT1 Protein

• Background:

  Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated; STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF) ; migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes; inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.

• Abbreviation:

  STAT1

• Synonyms:

  CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91; Signal Transducer and Activator of Transcription 1-Alpha/Beta; Transcription Factor ISGF-3 Components p91/p84

• UniProt:

  P42224

• Accession Number:

  P42224

• Expression System:

  E.coli

• Tag:

  None

• Sequence:

  Met 1-Val712

• Field of Research:

  Signal Transduction, Epigenetics and Nuclear Signaling, Cancer

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 68 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  83.3 kDa

• Observed Molecular Weight:

  85 kDa

• Species:

  Human