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STAT1 Monoclonal Antibody

CAT: 0763-E-AB-22205-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-22205-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs) . Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Abbreviation
STAT1 Mouse (5H7)
UniProt
P42224
Host
Mouse
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic Peptide of STAT1
Target
Signal transducer and activator of transcription 1 91kD; CANDF7; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF 3; ISGF-3; OTTHUMP00000163552; OTTHUMP00000165046; OTTHUMP00000165047; OTTHUMP00000205845; Signal transducer and activator of transcription 1 91kDa; Signal transducer and activator of transcription 1; Signal transducer and activator of transcription 1;91kD; Signal transducer and activator of transcription 1-alpha/beta; STAT 1; Stat1; STAT1; STAT91; Transcription factor ISGF 3 components p91 p84; Transcription factor ISGF-3 components p91/p84
Clonality
Monoclonal
Clone
Clone:5H7
Conjugation
Unconjugated
Applications
IHC-p
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Signal Transduction
Purification
Protein A purification
Concentration
1 mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P42224

Signal transducer and activator of transcription 1-alpha/beta

STAT1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42224
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STAT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K989, B2RCA0, D2KFR8, D3DPI7, Q53S88, Q53XW4, Q68D00, Q9UDL5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionTranscriptionTranscription regulation

Domain

Coiled coilSH2 domain

Cellular component

CytoplasmNucleus

Disease

Disease variant

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