Recombinant Human PDCD4/H731 Protein (His Tag)

• Background:

  Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation initiation and cap-dependent translation.PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation.

• Abbreviation:

  PDCD4; H731

• Synonyms:

  H731; Neoplastic Transformation Inhibitor Protein; Nuclear Antigen H731-Like; PDCD4; Programmed Cell Death Protein 4; Protein 197/15a

• UniProt:

  Q53EL6

• Accession Number:

  Q53EL6

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  Lys212-Pro357

• Field of Research:

  Cell biology; Cancer; epigenetics and nuclear signal

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  17.0 kDa

• Observed Molecular Weight:

  17 kDa

• Species:

  Human