Recombinant Human KIR2DL3/NKAT2 Protein (Fc Tag)

• Background:

  Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8) . KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

• Abbreviation:

  KIR2DL3; NKAT2

• Synonyms:

  CD158 antigen-like family member B2; CD158b2; KIR-023GB; KIR2DL3; Killer cell immunoglobulin-like receptor 2DL3; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT-2; NKAT2; p58 NK receptor CL-6

• UniProt:

  P43628

• Accession Number:

  P43628

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  His22-His245

• Field of Research:

  Immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  51.7 kDa

• Observed Molecular Weight:

  70-80 kDa

• Species:

  Human