Recombinant Human IGF-II/IGF2 Protein

Recombinant Human IGF-II/IGF2 Protein

• Background: Insulin-Like Growth Factor II (IGF2) belongs to the insulin family of polypeptide growth factors that is involved in development and growth. Members of this family are structurally homologous to proinsulin, and share higher sequence identity. IGF2 is expressed only from the paternally inherited allele and believed to be secreted by the liver and to circulate in the blood. IGF2 possess growth-promoting activity and can stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF2 is influenced by placental lactogen and may play a role in fetal development.
• Abbreviation: IGF-II;IGF2
• Synonyms: IGF-II, IGF2, Insulin-Like Growth Factor II, PP1446, Somatomedin-A
• CAS Number: 9000-83-3
• UniProt: P01344
• Accession Number: P01344
• Host: E. coli
• Origin Species: Human
• Tag: N-His
• Sequence: Ala25-Glu91
• Applications: Cell culture
• Field of Research: Signal Transduction;Cancer;Developmental Biology;
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to induce MCF-7 cells proliferation. The ED₅₀ for this effect is <3 ng/mL. The specific activity of recombinant human IGF-II is > 3x 10⁵ IU/mg.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 11 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.