Recombinant Human Fumarase/FH Protein

Recombinant Human Fumarase/FH Protein

• Background: Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.
• Abbreviation: Fumarase;FH
• Synonyms: FH, FMRD, Fumarase, Fumarate Hydratase Mitochondrial, HLRCC, LRCC, MCL, MCUL1
• CAS Number: 9000-83-3
• UniProt: P07954
• Accession Number: P07954
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Ala45-Lys510
• Field of Research: Signal Transduction;Cancer;metabolism;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 45 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.