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FH Polyclonal Antibody

CAT: 0763-E-AB-11249-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-11249-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Abbreviation
FH
UniProt
P07954
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human FH
Target
FH; Fumarase; Fumarate hydratase; Fumarate hydratase mitochondrial; Fumarate hydratase; mitochondrial; FUMH; HLRCC; LRCC; MCL; MCUL 1; MCUL1; MS709; Multiple hereditary cutaneous leiomyomata
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
55kDa
Isotype
IgG

UniProtKB · P07954

Fumarate hydratase, mitochondrial

FUMH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07954
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FH
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Fumarase, HsFH
EC number
4.2.1.2
Processing
Precursor
Secondary accessions
B1ANK7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative initiation

Cellular component

ChromosomeCytoplasmMitochondrionNucleus

Disease

Disease variantTumor suppressor

Biological process

DNA damageDNA repairTricarboxylic acid cycle

Molecular function

Lyase

Domain

Transit peptide

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