Recombinant Human FGF-1/FGFa Protein
CAT:
763-PKSH032430-02
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human FGF-1/FGFa Protein
- Background: FGF acidic; also known as ECGF; FGF-1and HBGF-1; is a non-glycosylated heparin binding growth factor that is expressed in the brain; kidney; retina; smooth muscle cells; bone matrix; osteoblasts; astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal; ectodermal; and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta; exported to the cytosol; dephosphorylated; and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.
- Abbreviation: FGF-1;FGFa
- Synonyms: Acidic Fibroblast Growth Factor, ECGFHeparin-Binding Growth Factor 1, Endothelial Cell Growth Factor, FGF-1, FGF1, FGFA, Fibroblast Growth Factor 1, HBGF-1, aFGF
- CAS Number: 9000-83-3
- UniProt: P05230
- Accession Number: P05230
- Host: E. coli
- Origin Species: Human
- Tag: None
- Sequence: Ala2-Asp155
- Field of Research: Signal Transduction;Cardiovascular;Neuroscience;Cancer;
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 17 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.