Recombinant Human CXCL7/NAP-2 Protein

Recombinant Human CXCL7/NAP-2 Protein

• Background: Human Chemokine (C-X-C motif) Ligand 7 (CXCL7); also known as neutrophil activating peptide 2 (NAP-2); is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines; such as IL-8 and the GRO proteins; CXCL7 binds CXCR2; chemoattracts and activates neutrophils. CXCL7; Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG); are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII; βTG; and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains; these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
• Abbreviation: CXCL7;NAP-2
• Synonyms: C-X-C Motif Chemokine 7, CTAP3, CXCL7, LDGF, Leukocyte-Derived Growth Factor, MDGFSmall-Inducible Cytokine B7, Macrophage-Derived Growth Factor, PBP, PPBP, Platelet Basic Protein, SCYB7, TGB1, THBGB1
• CAS Number: 9000-83-3
• UniProt: P02775
• Accession Number: P02775
• Host: E. coli
• Origin Species: Human
• Tag: N-His
• Sequence: Ala59-Asp128
• Applications: Cell culture
• Field of Research: Signal Transduction;Cardiovascular;immunology;
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2.The ED₅₀ for this effect is <0.5 ng/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 11 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.