Recombinant Human CCL2/MCP-1 Protein

Recombinant Human CCL2/MCP-1 Protein

• Background: The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.
• Abbreviation: CCL2;MCP-1
• Synonyms: C-C motif chemokine 2, CCL2, HC11, MCAF, MCP-1, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, Monocyte chemotactic protein 1, Monocyte secretory protein JE, Small-inducible cytokine A2
• CAS Number: 9000-83-3
• UniProt: P13500
• Accession Number: P13500
• Host: E. coli
• Origin Species: Human
• Tag: N-His
• Sequence: Gln24-Thr99
• Applications: Cell culture
• Field of Research: Cardiovascular;Cancer;immunology;metabolism
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measure by its ability to chemoattract BaF3 cells transfected with human CCR2A.The ED₅₀ for this effect is <20 ng/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 11 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.