Recombinant Human Calreticulin-3/CALR3 Protein

Recombinant Human Calreticulin-3/CALR3 Protein

• Background: Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.
• Abbreviation: Calreticulin-3;CALR3
• Synonyms: CALR3, CRT2, Calreticulin-3, calreticulin-2, calsperin
• CAS Number: 9000-83-3
• UniProt: Q96L12
• Accession Number: Q96L12
• Host: E. coli
• Origin Species: Human
• Tag: None
• Sequence: Thr 20-Leu384
• Field of Research: Signal Transduction;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 40-50 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.