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Recombinant Human EphA4 Protein

CAT: 0763-PKSH032008-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH032008-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ephrin type-A receptor 4 (EPHA4) belongs to the protein kinase superfamily and Ephrin receptor subfamily. EPHA4 contains 1 Eph LBD domain; 2 fibronectin type-III domains; 1 protein kinase domain and 1 SAM domain. EPH and EPH-related receptors have been implicated in mediating developmental events; particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Abbreviation
EphA4
Synonyms
EK8; EPH-like kinase 8; EPHA4; Ephrin type-A receptor 4; HEK8; SEK; TYRO1; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK; hEK8
UniProt
P54764
Accession Number
P54764
Expression System
HEK293 Cells
Tag
None
Sequence
Val20-Thr547
Field of Research
Signal Transduction; Cardiovascular; Neuroscience
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
59.2 kDa
Observed Molecular Weight
60-80 kDa
Species
Human

UniProtKB · P54764

Ephrin type-A receptor 4

EPHA4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54764
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHA4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A8K2P1, B2R601, B7Z6Q8, Q2M380
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell adhesionNeurogenesis

Cellular component

Cell junctionCell membraneCell projectionEndosomeMembranePostsynaptic cell membraneSynapse

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

PTM

GlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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