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Recombinant E2F1 Monoclonal Antibody

CAT: 0763-E-AB-81553-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-81553-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.
Abbreviation
E2F1
UniProt
Q01094
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human E2F1
Target
E2F-1; RBAP1; RBBP3; RBP3; E2F1
Clonality
Monoclonal
Clone
R03-5G3
Conjugation
Unconjugated
Applications
WB; IHC-P; IF
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000; IHC 1:20-1:100; IF 1:50-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
47kDa
Observed Molecular Weight
70kDa
Isotype
IgG

UniProtKB · Q01094

Transcription factor E2F1

E2F1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01094
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
E2F1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
E2F-1
EC number
—
Processing
—
Secondary accessions
Q13143, Q92768
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Biological process

ApoptosisCell cycleHost-virus interactionTranscriptionTranscription regulation

Cellular component

Nucleus
Product Datasheet
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