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Recombinant E2F-1 Monoclonal Antibody

CAT: 0763-AN301368LSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0763-AN301368LSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member ofThe E2F family of transcription factors.The E2F family plays a crucial role inThe control of cell cycle and action of tumor suppressor proteins and is also a target ofThe transforming proteins of small DNA tumor viruses.The E2F proteins contain several evolutionally conserved domains found in most members ofThe family. These domains include a DNA binding domain, a dimerization domain which determines interaction withThe differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded withinThe transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.
Abbreviation
E2F-1
UniProt
Q01094
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human E2F-1 protein
Target
RBP; RBAP; RBBP; E2F; E2F-1; RBAP1; RBBP3; RBP3; E2F1
Clonality
Monoclonal, Recombinant
Clone
5F4
Conjugation
Unconjugated
Applications
WB
Field of Research
Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
47 kDa
Observed Molecular Weight
60 kDa
Isotype
IgG, κ

UniProtKB · Q01094

Transcription factor E2F1

E2F1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q01094
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
E2F1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
E2F-1
EC number
—
Processing
—
Secondary accessions
Q13143, Q92768
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Biological process

ApoptosisCell cycleHost-virus interactionTranscriptionTranscription regulation

Cellular component

Nucleus

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