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Histone H4 Polyclonal Antibody

CAT: 0763-E-AB-70364-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-70364-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.
Abbreviation
Histone H4
UniProt
P62805
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein corresponding to human Histone H4
Target
H4; H4F2; H4FN; HIST1H4; HIST2H4; Hist4h4; HISTH4H4; Histone H4; methyl histone H4; methylated histone H4
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
1.8 mg/mL
Dilution
IHC 1:300-1:1000
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P62805

Histone H4

H4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P62805
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
H4C1, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A2VCL0, P02304, P02305, Q6DRA9, Q6FGB8, Q6NWP7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationCitrullinationHydroxylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Coding sequence diversity

Chromosomal rearrangement

Cellular component

ChromosomeNucleosome coreNucleus

Disease

Disease variantIntellectual disability

Molecular function

DNA-binding
Product Datasheet
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